Trials / Unknown
UnknownNCT03675464
Study of Human Adipose Tissue (LOSHAT)
Longitudinal Observational Study of Human Adipose Tissue (LOSHAT)
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,500 (estimated)
- Sponsor
- Karolinska University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Accepted
Summary
The investigators will study the influence of initial fat cell size/number and adipose function (in particular lipolysis) on weight development over very long time periods (years). By comparing investigations of fat biopsies or blood samples obtained at baseline, the investigators will determine the association between adipose morphology/function and changes in weight or development of metabolic complications (e.g. metabolic syndrome, glucose intolerance, type 2 diabetes, dyslipidemia and hypertension).
Detailed description
The investigators will ask all subjects that have previously been examined at the investigators laboratory (from 1992 and forward) in studies of adipose tissue function if they are interested to participate in a new study. Previously obtained results from examinations of adipose tissue, anthropometric measurements and blood samples will be used as baseline. In addition, saved blood samples and samples from old fat biopsies can be re-investigated in some cases. The new investigation includes a questionnaire that the subjects can answer by mail or email. In addition, anthropometric measurements and blood pressure determination will be performed at a primary health care center and blood samples will be collected for analysis of fasting glucose, HbA1C and lipids. Information regarding all previously investigated subjects will also be collected from several Swedish national patient registries such as the Patient Register, Prescribed Drug register and Cause-of Death register.
Conditions
- Weight Change, Body
- Weight Loss
- Weight Gain
- Lipolysis
- Adipose Tissue
- Human
- Obesity
- Type 2 Diabetes Mellitus
Timeline
- Start date
- 2018-09-20
- Primary completion
- 2022-12-31
- Completion
- 2023-12-31
- First posted
- 2018-09-18
- Last updated
- 2020-09-04
Locations
1 site across 1 country: Sweden
Source: ClinicalTrials.gov record NCT03675464. Inclusion in this directory is not an endorsement.