NCT03675412

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Acute Changes in Optic Nerve Head (ONH) and Macular Blood Flow After Caffeine Consumption in Glaucoma Patients and Healthy Subjects: A Quantitative Optic Coherence Tomography Angiography (OCTA) Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Wills Eye · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Detailed description

Ingestion of caffeine in glaucoma patients and healthy subjects may decrease peripapillary and macular blood flow in the back of the eye. The primary objective of this study is to assess the acute changes in peripapillary and macular blood flow before and after an intake of oral caffeine (200 milligram tablet) in glaucoma patients and healthy subjects by using optical coherence tomography angiography (OCTA) scans. This novel imaging tool creates three-dimensional angiograms to assesses signal changes caused by flowing blood cells in a non-invasive angiogram scan. Blood flow is shown as vessel density measured in percentage.

Conditions

• Glaucoma, Primary Open Angle

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Caffeine tablet	Each eligible participant will receive one 200 mg caffeine tablet to ingest after completing all baseline study tasks.

Timeline

• Start date: 2018-12-30
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2018-09-18
• Last updated: 2025-11-14

Locations

1 site across 1 country: United States