NCT03675100

Neurotrophic Factors, Tight Junction Proteins, and Cytokines in IBS

Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.

Conditions

• Irritable Bowel Syndrome
• Tight Junction Alteration
• Pathophysiology

Interventions

Type	Name	Description
PROCEDURE	colonoscopic mucosal biopsy	colonoscopic mucosal biopsy was undertaken for every participant

Timeline

• Start date: 2009-06-01
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2018-09-18
• Last updated: 2020-03-24

Locations

1 site across 1 country: South Korea