NCT03672669

Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Comparison of the Effect of Advanced Platelet-rich Fibrin and Leukocyte- and Platelet-rich Fibrin on Outcomes After Removal of Impacted Mandibular Third Molar: A Randomised Split-mouth Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 27 (actual)
• Sponsor: Near East University, Turkey · Academic / Other
• Sex: All
• Age: 18 Years – 26 Years
• Healthy volunteers: Accepted

Summary

In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.

Conditions

• Pain, Postoperative
• Trismus
• Swelling

Interventions

Type	Name	Description
GENETIC	Advanced Platelet Rich Fibrin (A-PRF)	blood samples collected in 10 ml of vacuumed plain glass tubes were centrifuged for 14 minutes at 1500 rpm without anticoagulant agents in order to obtain A-PRF
GENETIC	Leukocyte- and platelet-rich fibrin (L-PRF)	blood samples collected in 10 ml of glass coated plastic tubes were centrifuged without anticoagulant agents for 10 minutes in order to obtain L-PRF

Timeline

• Start date: 2017-11-05
• Primary completion: 2018-03-01
• Completion: 2018-05-20
• First posted: 2018-09-14
• Last updated: 2018-09-14

Locations

1 site across 1 country: Turkey (Türkiye)