NCT03667131

Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis.

Effect of Prophylactic Treatment With Enalapril Maleate on Arterial Stiffness in Rheumatoid Arthritis Patients.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 59 (actual)
• Sponsor: University of Guadalajara · Academic / Other
• Sex: Female
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effect in artery stiffness of enalapril maleate in Rheumatoid Arthritis women patients. Half of participants will receive 5 mg enalapril maleate every 12 hrs, while the other half will receive a placebo.

Detailed description

Rheumatoid Arthritis (RA) is a chronic inflammatory systemic disease considered as an independent cardiovascular risk factor that is associated with cumulative inflammatory load with an elevation of circulating levels of cytokines, which mediate the mechanism of endothelial cells activation by increasing the angiotensin converting enzyme (ACE) function and generation of vasoconstriction. Enalapril maleate is a prodrug that is hydrolyzed by hepatic esterases in enalaprilat, which is a potent inhibitor of ACE. ACE inhibition decreases vascular systemic resistance and mean, diastolic and systolic blood pressures in several hypertensive states, independently of the mechanism, ACE inhibitors have a widespread clinic use for cardiovascular diseases. Therefore, the researchers considered that there could be an association between the use of enalapril and the decrease in arterial stiffness.

Conditions

• Rheumatoid Arthritis

Interventions

Type	Name	Description
DRUG	Enalapril Maleate	Enalapril Maleate 5 mg tablet, every 12 hrs for 90 days.
DRUG	Placebo	Placebo 5 mg tablet, every 12 hrs for 90 days.

Timeline

• Start date: 2017-02-13
• Primary completion: 2017-12-08
• Completion: 2018-02-19
• First posted: 2018-09-12
• Last updated: 2018-11-14

Locations

1 site across 1 country: Mexico