NCT03660163

Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.

Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography-A Prospective Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 65 (actual)
• Sponsor: King's College London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to assess the correlation between pre-obturation bacterial detection using fluorescence amplification and outcome of endodontic treatments. Thus, enabling a suitable detection threshold to predict the likelihood of treatment failure. This has the potential to be used a bench side tool in general dental practice to act as a surrogate endpoint for clinicians performing root canal treatment.

Detailed description

Pre-obturation root canal samples were taken using paper points from patients undergoing primary root treatments. The samples were analyzed using a fluorescent spectrometer and a molecular fluorescent vital dye (Calcein AM). Pre-operative and 1-year post-operative periapical radiographs and Cone Beam Computed Tomography (CBCT) scans were assessed by two calibrated expert examiners to evaluate the outcome of the root canal treatments. The use of a chairside bacterial stain can allow the clinician to predict the outcome of treatment with confidence. Sampling the root canal space with endodontic paper points followed by ex-situ fluorescent staining and analysis provides a patient-friendly, simple to use and rapid way of predicting root canal treatment outcome.

Conditions

• Periapical Periodontitis

Timeline

• Start date: 2016-11-01
• Primary completion: 2018-08-01
• Completion: 2019-08-01
• First posted: 2018-09-06
• Last updated: 2018-09-07