NCT03659890

Dietary Nucleotides and Ribose on Muscle Fuel Utilisation

The Effect of Dietary Nucleotides and Ribose on Muscle Fuel Utilisation and Exercise Performance

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of Exeter · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP. Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored. This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Low nucleotide	2 week, twice daily, supplementation with a nucleotide-depleted mycoprotein drink, with added dextrose
DIETARY_SUPPLEMENT	High nucleotide	2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added dextrose
DIETARY_SUPPLEMENT	High nucletide + Ribose	2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added ribose

Timeline

• Start date: 2018-06-28
• Primary completion: 2020-02-02
• Completion: 2020-02-02
• First posted: 2018-09-06
• Last updated: 2020-03-26

Locations

1 site across 1 country: United Kingdom