NCT03655925

Human Leucocyte Antigen G and Chronic Heart Failure

Plasma Levels of Human Leucocyte Antigen G in Patients With Chronic Heart Failure

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Piera Boschetto · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The Human leukocyte antigen G (HLA-G) is a non-classical, major histocompatibility complex class I (MHC-I) protein that modulates the immune response, inhibiting it in most cases. Physiologically expressed in the cells of some tissues, it increases in inflammatory reactions. Inflammation appears to play an important role in the development of chronic heart failure. This study aims to evaluate the levels of soluble HLA-G in patients with heart failure and to investigate the relationships between HLA-G and other clinical-functional parameters of the disease. Investigators hypothesize that the plasma levels of HLA-G could correlate with the clinical status of heart failure and could provide indications on patient's prognosis.

Conditions

• Chronic Heart Failure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	plasmatic HLA-G	plasmatic HLA-G by blood sample

Timeline

• Start date: 2017-10-11
• Primary completion: 2019-03-31
• Completion: 2019-03-31
• First posted: 2018-08-31
• Last updated: 2019-04-17

Locations

1 site across 1 country: Italy