NCT03655457

Evaluation of the Efficacy of Surfaktant in Preterm Infants by Lung Ultrasound

Evaluation of the Efficacy of Different Surfactant Preparations in Preterm Infants by Lung Ultrasound

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: Zekai Tahir Burak Women's Health Research and Education Hospital · Academic / Other
• Sex: All
• Age: 1 Hour – 6 Hours
• Healthy volunteers: Not accepted

Summary

To compare the lung ultrasound scores after two different natural surfactant administration as a parameter reflecting lung inflation. Poractant alfa decreases lung ultrasound scores as efficient as beractant treatment

Detailed description

Outcomes: Improvement of Lung usg scores after surfactanct and the difference between groups at different time points (2nd and 6hr). Secondary outcome: The correlation between lung usg scores and clinical scores (silverman scores), FiO2 and PCO2 levels, failure of weaning to noninvasive ventilation after surfactant Preterm infants of 32 gestational weeks and below, who admit to the NICU with signs of respiratory distress, treated with non invasive or mechanical ventilation and require surfactant treatment in 6 hours of life will be enrolled.

Conditions

• Lung Ultrasound Scores

Interventions

Type	Name	Description
DEVICE	group 1 Poractant alfa	Comparison of lung usg scores in infants treated with Poractant alfa and Beractant: 0 indicates A-pattern (defined by the presence of the only A-lines); 1, B-pattern (defined as the presence of ≥3 well-spaced B-lines); 2, severe B-pattern (defined as the presence of crowded and coalescent B-lines with or without consolidations limited to the subpleural space); and 3, extended consolidations.
DEVICE	group 2 beractant	lComparison of lung usg scores in infants treated with Poractant alfa and Beractant: 0 indicates A-pattern (defined by the presence of the only A-lines); 1, B-pattern (defined as the presence of ≥3 well-spaced B-lines); 2, severe B-pattern (defined as the presence of crowded and coalescent B-lines with or without consolidations limited to the subpleural space); and 3, extended consolidations.

Timeline

• Start date: 2018-03-21
• Primary completion: 2019-01-30
• Completion: 2019-02-28
• First posted: 2018-08-31
• Last updated: 2018-12-11

Locations

1 site across 1 country: Turkey (Türkiye)