NCT03651713

Hyperglycemia, Exercise, and Endothelial Function

Effect of Short-Term Glucose Loading on Vascular Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Detailed description

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Conditions

• Endothelial Function
• Hyperglycemia

Interventions

Type	Name	Description
BEHAVIORAL	GLU+EX	Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.
DIETARY_SUPPLEMENT	GLU	Subjects will consume a 75g glucose beverage three times daily over a seven-day period.

Timeline

• Start date: 2018-10-15
• Primary completion: 2019-10-21
• Completion: 2019-10-21
• First posted: 2018-08-29
• Last updated: 2020-03-24

Locations

1 site across 1 country: United States