Trials / Completed
CompletedNCT03651661
Pupillography as Screening Tool for Brain Insulin Resistance
Pupillographie Als Screeningtest für Cerebrale Insulinresistenz
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 22 (actual)
- Sponsor
- University Hospital Tuebingen · Academic / Other
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
Cerebral insulin action is important in the regulation of whole body glucose metabolism. However, the cerebral insulin action differs between individuals - there is a so called cerebral insulin resistance. The influence of central insulin action on peripheral metabolism seems at least partially mediated via the autonomous nervous system. A noninvasive method to measure autonomic function is the pupillography. The aim of the study is to find out whether pupillography can be used to assess central insulin activity. Thus, pupillography will be performed in 30 normal weight and 30 overweight subjects before and after application insulin intranasally.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | human insulin | human insulin administered as nasal spray |
| DRUG | placebo | placebo administered as nasal spray |
| DIAGNOSTIC_TEST | Pupillography | Autonomic tone will be adressed by pupillography using the F2D2 (Amtech Germany) device. |
Timeline
- Start date
- 2018-07-03
- Primary completion
- 2018-11-01
- Completion
- 2019-01-07
- First posted
- 2018-08-29
- Last updated
- 2019-01-10
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT03651661. Inclusion in this directory is not an endorsement.