NCT03648619

Automatized "Semi-Whole-Body"-MRI Protocol for Cancer Staging

Evaluation of an Innovative Automatized "Semi-Whole-Body"-MRI Protocol to Increase Patient Comfort and Cost-effectiveness of Oncologic Imaging

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Kantonsspital Baden · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aims of this study are * to evaluate the image quality and robustness of a whole-body MRI protocol by using an innovative partially automatic algorithm (DOT engine), that automatically optimizes protocol parameters depending on body region (e.g. thorax versus abdomen) * to compare lesion detectability between wb-MRI and the gold standard positron emission tomography (PET)/CT * to compare patient comfort between PET/CT and wb-MRI using a dedicated questionnaire * to compare duration of image acquisition with regards to cost-effectiveness

Detailed description

Whole-body imaging becomes increasingly important in oncologic patients not only for primary cancer staging, but also for assessment of response to therapy. So far, PET/CT is a key method to assess cancer-related changes of metabolism in tumors, which is crucial for response evaluation and to differentiate between benign and malignant lesions. Limitations of PET/CT include the assessment of sclerotic bone metastasis, which often do not show increased tracer uptake. Certain organ metastasis (especially in brain and liver) are also barely detectable due to physiologically increased uptake. Moreover, both CT and administration of radioactive tracer are associated with radiation exposure for patients. Whole-body MRI (wb-MRI) including functional techniques (e.g. Diffusion-weighted Imaging (DWI) to evaluate cell density) enables a functional staging and therapy assessment without use of ionizing radiation. Advantages to assess sclerotic bone lesions and organ metastases have been confirmed in recent literature. Limitations of MRI include detection of lesions in organs with high susceptibility and motion like the thorax.

Conditions

• Oncology

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Semi whole-body MRI	Single semi-automatic, semi whole-body MRI protocol (Dot engine)

Timeline

• Start date: 2017-09-01
• Primary completion: 2018-09-01
• Completion: 2018-09-01
• First posted: 2018-08-27
• Last updated: 2021-09-09

Locations

1 site across 1 country: Switzerland