Trials / Completed
CompletedNCT03648021
The Effect of Paracetamol on Brain Temperature
NEUROTHERM: The Effect of Paracetamol on Brain Temperature in Acute Brain Injury in a Neuro Critical Care Unit: A Randomized Controlled Trial
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 100 (actual)
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The main objective of this study is to compare the effect of intravenous paracetamol administration on mean brain temperature (measured between H0 and H6) in patients with cerebral hyperthermia versus placebo. The investigators will measure brain temperature using a thermistor that will be connected to the intracranial pressure transducer.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Paracetamol | \>50kg: Paracetamol 1 gramme in a solution of 10mg/mL administred intravenously. 1 dose \>50kg: Paracetamol 15mg/kg/dose in a solution 10mg/mL administred intravenously. 1 dose |
| DRUG | Placebo | 100mL of chlorure de sodium 0.9% administred intravenously. 1 dose |
Timeline
- Start date
- 2018-05-03
- Primary completion
- 2022-05-26
- Completion
- 2022-05-26
- First posted
- 2018-08-27
- Last updated
- 2023-07-27
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03648021. Inclusion in this directory is not an endorsement.