NCT03647787

White Matter Integrity According to BDNF Genotype After Stroke

Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 58 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.

Detailed description

The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the intrahemispheric connection from M1 to ventral premotor cortex (M1PMv), and the other is the interhemispheric connection between bilateral M1s (CC). There were also to investigate the relationships between motor impairment and tract-related FA of white matter tracts in each BDNF genotype

Conditions

• Stroke

Interventions

Type	Name	Description
OTHER	observational study	This study is a longitudinal observational study

Timeline

• Start date: 2018-05-25
• Primary completion: 2019-04-05
• Completion: 2019-04-05
• First posted: 2018-08-27
• Last updated: 2019-09-19

Locations

1 site across 1 country: South Korea