NCT03647644

Coagulation Test Changes Associated With Acute Normovolemic Hemodilution in Cardiac Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The researchers are trying to reduce the need for blood transfusions in subjects having surgery that will involve the use of cardiopulmonary bypass. A unit of whole blood will be removed as part of their standard of care prior to going on cardiopulmonary bypass (CPB). This unit is given back to the subject post CPB. This has been shown to reduce the need for blood transfusion in patients.

Detailed description

Subjects will be asked to allow the researchers to take the blood left over from normal standard of care blood draws and do coagulation testing. If clinically indicated, the blood, about 2 units, will be withdrawn from the subject. The researchers will also collect 8 ml (less than two teaspoons) of blood through the catheter that was placed as part of standard of care.

Conditions

• Coagulation Disorder
• Bleeding

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Coagulation Laboratory Testing	Standard coagulation testing (Platelet count, Fibrinogen, PT/INR, aPTT), and Thromboelastogram as is routine and per institutional protocol in this population.

Timeline

• Start date: 2018-01-31
• Primary completion: 2018-10-11
• Completion: 2018-10-11
• First posted: 2018-08-27
• Last updated: 2019-01-07

Locations

1 site across 1 country: United States