NCT03646825

Effect of Natural Antioxidant Supplement on Sperm DNA Fragmentation

Observation Study of the Effect of Use of Natural Antioxidant Supplement on Sperm DNA Fragmentation

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 54 (actual)
• Sponsor: Colorado Center for Reproductive Medicine · Academic / Other
• Sex: Male
• Age: 18 Years – 55 Years
• Healthy volunteers: —

Summary

Observational study to see the effect of use of natural Antioxidant supplement on sperm DNA fragmentation. Subjects will take the natural antioxidant for 3 months prior to repeat testing.

Detailed description

Male patients will be recruited based on having a high DNA fragmentation (chromatin \>16) no other severe male factor infertility (\>5million/ml, count, \> 10%motility and \>1% morphology) and sufficient ejaculate sperm for ICSI (no surgically removed sperm or history of vasectomy reversal). Patients will be provided the natural antioxidant supplementation by the sponsor. Patients will take 1 capsule orally 3 times a day for a full 12 weeks. Sperm DNA structure will be re-assessed after completion of 12 weeks of antioxidant to compare to baseline sperm DNA structure collected prior to starting regimen of supplement daily

Conditions

• Observe Effect of Antioxidant on Sperm DNA Fragmention

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Natural Antioxidant supplement	1 capsule orally three times a day for 12 weeks

Timeline

• Start date: 2018-08-01
• Primary completion: 2022-06-15
• Completion: 2022-10-01
• First posted: 2018-08-24
• Last updated: 2023-02-23

Locations

1 site across 1 country: United States