Trials / Unknown
UnknownNCT03645278
The PK/PD Study of SHR0532 Tablets in Healthy Subjects
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR0532 Tablets in Healthy Subjects
- Status
- Unknown
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd. · Industry
- Sex
- All
- Age
- 18 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
In the last four decades, several classes of diuretics have been the first line option for the therapy of widespread hypertension. However, all the classes of diuretics cause alteration of potassium homeostasis. The primary objective of this study is to assess the safety and tolerability of SHR0532 tablets in healthy subjects. In addition, this study will provide information on Pharmacokinetics and Pharmacodynamics of SHR0532 tablets in healthy subjects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | SHR0532 | Ascending dose oral adminstration |
| DRUG | Placebo | Ascending dose oral administration |
Timeline
- Start date
- 2018-08-24
- Primary completion
- 2018-12-15
- Completion
- 2019-04-30
- First posted
- 2018-08-24
- Last updated
- 2018-08-24
Source: ClinicalTrials.gov record NCT03645278. Inclusion in this directory is not an endorsement.