NCT03644472

Postmenopausal Women and Their Endothelium

Postmenopausal Women and Their Endothelium: Is Dietary Nitrate Supplementation Protective

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: Penn State University · Academic / Other
• Sex: Female
• Age: 70 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to test the effects of a one time dose and 7-days of inorganic nitrate (supplied in the form of beetroot juice) on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.

Detailed description

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. Function of the endothelium has been shown to decline across the menopause transition, resulting in less production of nitric oxide. As such the investigators are investigating a potential therapeutic strategy in women have recently undergone menopause to boost nitric oxide availability.

Conditions

• Postmenopausal Women

Interventions

Type	Name	Description
DRUG	nitrate rich beetroot juice	This beverage contains 0.3 g of inorganic nitrate per 70 ml container, and is bottled and supplied by James White Drinks (UK).
DRUG	nitrate depleted beetroot juice	This beverage is identical in look and taste to the Beet-It organic shot, but has the nitrate removed. It is also bottled and supplied by James White Drinks (UK).

Timeline

• Start date: 2018-11-07
• Primary completion: 2023-02-20
• Completion: 2023-02-20
• First posted: 2018-08-23
• Last updated: 2023-02-27

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study