NCT03644290

Cognitive Training in Stroke Patients

Neural Correlates and Functional Connectivity Associated With Cognitive Memory Training in Patients With Cerebral Ischemic Lesions

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: São Paulo State University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke

Detailed description

The study will investigate the effects of two cognitive training strategies on behavior, neural correlates and functional connectivity of patients with vascular lesions. The first strategy is associated to the ability to apply efficient organizational semantic category strategy to a list of words. This strategy will be trained in activities similar to everyday life activities. There will be in total 5 sessions, two for measuring the generalization effects before and after training and three sessions to apply the semantic strategy in order to improve encoding and episodic memory performance. The second strategy is related to the ability to remember face-names and the strategy will involve the identification of a salient face feature, creation of a nickname and association of the nickname to the real name. There will be 5 sessions in total, two for measuring the generalization effects before and after training and three sessions to apply the face-name association strategy in order to improve encoding and episodic memory performance. These two cognitive training procedures will be carried out in two separate moments. Before and after each procedure all participants will be examined by functional MRI during resting state and during a active task using a memory encoding paradigm. The same procedure will be carried out with normal control participants.

Conditions

• Vascular Diseases

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive training	Five sessions of semantic strategy training and face-name association training
BEHAVIORAL	Control Condition	Five sessions of active control information and education

Timeline

• Start date: 2015-01-02
• Primary completion: 2018-02-01
• Completion: 2023-12-31
• First posted: 2018-08-23
• Last updated: 2023-11-28

Locations

1 site across 1 country: Brazil