NCT03642899

OCT Angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy

Study of Peripapillary Vasculature With OCT-angiography in Arteritic and Non Arteritic Anterior Ischemic Neuropathy After Oedema Disappearance

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 17 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Anterior ischaemic optic neuropathy results from infarction of retrolaminar portion of the optic nerve head, caused by occlusion of the posterior ciliary artery. Non arteritic anterior ischaemic optic neuropathy affects more frequently people between 50 and 70 years of age, with vasculopathic risk factors. Arteritic anterior ischaemic optic neuropathy is caused by the Horton disease, affects an older population and is an ophthalmologic emergency because of the bilateralisation's risk. The aim of this study is to compare the peripapillar vascular density of anterior ischaemic optic neuropathy eyes (arteritic and non arteritic) with normal eyes after the disappearance of the papillar edema, with oCT-angiography. The investigators will include patients with anterior ischaemic optic neuropathy and normal patients. For each participant, the investigators will estimate the best visual acuity, intra-ocular pressure, make a fondus, measurement of retinal nervous layer thickness, ganglionar cells layer thickness, and a macular and papillar OCT angiography during a consultation (duration 30 min). The investigators will be able to know if * there is a modification of the peripapillary vascularisation subsequent to the occlusion of the posterior ciliary artery * there is a difference between arteritic and non arteritic anterior ischaemic optic neuropathy, * there is a repercussion of the neuropathy on the retinal layers, * there is a difference in peripapillar vascularisation by age.

Detailed description

Anterior ischaemic optic neuropathy results from infarction of retrolaminar portion of the optic nerve head, caused by occlusion of the posterior ciliary artery. Non arteritic anterior ischaemic optic neuropathy affects more frequently people between 50 and 70 years of age, with vasculopathic risk factors. Arteritic anterior ischaemic optic neuropathy is caused by the Horton disease, affects an older population and is an ophthalmologic emergency because of the bilateralisation's risk. The aim of this study is to compare the peripapillar vascular density of anterior ischaemic optic neuropathy eyes (arteritic and non arteritic) with normal eyes after the disappearance of the papillar edema, with oCT-angiography. The investigators will include patients with anterior ischaemic optic neuropathy and normal patients. For each participant, the investigators will estimate the best visual acuity, intra-ocular pressure, make a fondus, measurement of retinal nervous layer thickness, ganglionar cells layer thickness, and a macular and papillar OCT angiography during a consultation (duration 30 min). The investigators will be able to know if * there is a modification of the peripapillary vascularisation subsequent to the occlusion of the posterior ciliary artery * there is a difference between arteritic and non arteritic anterior ischaemic optic neuropathy, * there is a repercussion of the neuropathy on the retinal layers, * there is a difference in peripapillar vascularisation by age.

Conditions

• Neuropathy, Optic

Timeline

• Start date: 2018-08-29
• Primary completion: 2019-06-04
• Completion: 2019-06-04
• First posted: 2018-08-22
• Last updated: 2019-07-10

Locations

1 site across 1 country: France