NCT03639519

A Trial to Assess the Impact of Ascorbic Acid on Cardiac Surgeries Outcomes and Complications''

'A Prospective Randomized Trial to Assess the Impact of Ascorbic Acid on Outcomes and Complications Post Cardiac Surgeries''

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: El-Galaa Military Medical Complex · Other Government
• Sex: All
• Age: 21 Years
• Healthy volunteers: Not accepted

Summary

this study is evaluating the safety and efficacy of ascorbic acid as a drug that can decrease inflammatory complications post surgical in addition to its impact on decreasing risk of arrhythmia and total opioid administration post operative

Detailed description

The study will include two arm of patients who are scheduled for elective cardiac surgery, either coronary artery bypass grafting (CABG) or Valvular replacement First arm: Patients will take 2 g orally ascorbic acid effervescent tablets the night before cardiac surgery, then 1 g twice daily for 5 days after surgery in addition to their traditional medical care. Second arm: will not be given ascorbic acid , instead a placebo 9orange carbonated beverage) will be used, and will be given the rest of traditional medical care provided to the first arm. Inflammatory markers C- reactive protein (CRP), erythrocyte sedimentation rate (ESR) and differential total leukocytic count (TLC), serum urea and creatinine, ALT, AST, CK-mb, CK-Total, aPTT, INR, Hemoglobin, platelet count, will be assessed on day 0, 1,2,4,6 postoperative in both arms.

Conditions

• Cardiothoracic Surgery

Interventions

Type	Name	Description
DRUG	Ascorbic Acid 500Mg Chew Tab	Ascorbic acid will be administered at the night before surgery and will be continued for five days
OTHER	Carbonated orange beverage	The carbonated orange beverage will be administered at the night before surgery and will be continued for five days

Timeline

• Start date: 2018-04-15
• Primary completion: 2019-04-15
• Completion: 2019-08-15
• First posted: 2018-08-21
• Last updated: 2018-08-21

Locations

1 site across 1 country: Egypt