NCT03639376

Passive Smoking and LL-37 in Children

Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 180 (actual)
• Sponsor: Kırıkkale University · Academic / Other
• Sex: All
• Age: 6 Years – 12 Years
• Healthy volunteers: Accepted

Summary

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Detailed description

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors. Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity. LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated

Conditions

• Innate Immunity
• Periodontal Health

Timeline

• Start date: 2016-11-01
• Primary completion: 2018-04-01
• Completion: 2018-06-01
• First posted: 2018-08-21
• Last updated: 2018-08-21