NCT03637218

Acute Exposure of High Altitude on Cardiac Output

Acute Exposure of Simulated Hypoxia on Non-invasive Cardiac Output Assessments at Rest and During Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response High Altitude (Säntis; 2500m above sea level) on non-invasive cardiac output assessments by Finapres® NOVA Technology at rest and under exercise

Detailed description

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). During the exposure High Altitude (2500m) and Low Altitude (Zurich; 470m) up to 5 hours, the participants cardiac output non-invasively assessed will be measured repetitive during the whole intervention.

Conditions

• Pulmonary Hypertension

Interventions

Type	Name	Description
OTHER	Assessment at Low Altitude (470m above sea level)	Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
OTHER	Exposure to High Altitude (2500m above sea level)	Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2018-08-17
• Last updated: 2020-01-07

Locations

1 site across 1 country: Switzerland