NCT03637153

Acute Exposure to High Altitude on Exercise Capacity

Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.

Detailed description

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, 6MWT, pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m). Towards the end of the exposure after approximately 4 hours, the participants will perform a constant loaded exercise test on an Ergometer with a calculated resistance of their 60% max Workload. The patients will be encouraged to perform these tests up to their physical exhaustion.

Conditions

• Pulmonary Hypertension

Interventions

Type	Name	Description
OTHER	Assessment at Low Altitude (470m above sea level)	Assessment at Low Altitude (in Zurich; 470m above sea level) in order to compare this data with High altitude exposure
OTHER	Exposure to High Altitude (2500m above sea level)	Exposure to High Altitude (Säntis; 2500m above sea level) for approximately 5 hours

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-01-01
• Completion: 2019-01-01
• First posted: 2018-08-17
• Last updated: 2020-01-07

Locations

1 site across 1 country: Switzerland