NCT03637127

Acute Exposure of Simulated Hypoxia on Cognitive Function

Acute Exposure to Hypoxia in Precapillary Pulmonary Hypertension: Physiological and Clinical Effects at Rest and During Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) on cognitive functions.

Detailed description

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, six-minute walk test (6MWT), pulmonary function test, clinical assessment and blood gas Analysis. Randomly assigned to the order of testing, the participants will be tested under simulated altitude (FiO2: 15.1% with the "AMC Altitrainer") and shamed altitude with the same device. During the exposure to simulated altitude (FiO2: 15.1%) of approximately 1 hour, the participants will perform cognitive function test . The results will be compared under hypoxic and normal conditions.

Conditions

• Pulmonary Hypertension

Interventions

Type	Name	Description
DEVICE	Simulated Altitude (FiO2: 15.1%)	Inhalation of deoxygenated air through a altitude simulator ("Altitrainer"), for approx. 1 hour. given by a facemask.
DEVICE	Shamed Hypoxia (FiO2: 20.9)	Inhalation of unmodified air through an altitude Simulator ("Altitrainer") for approximately 1 hour given by a facemask

Timeline

• Start date: 2018-07-01
• Primary completion: 2019-04-01
• Completion: 2019-04-01
• First posted: 2018-08-17
• Last updated: 2020-01-07

Locations

1 site across 1 country: Switzerland