NCT03634566

Effect of N_Acetylcysteine on Liver Functions in Donors in Living Liver Transplantation

Effect of N_Acetylcysteine on Liver Functions in Donors in Living Donor Liver Transplantation

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis

Conditions

• Liver Transplant; Complications

Interventions

Type	Name	Description
DRUG	N-Acetylecysteine	N-Acetylecysteine 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days
DRUG	Placebo	Ringer acetate continuous infusion at the same rate for 2 days.

Timeline

• Start date: 2018-04-01
• Primary completion: 2019-02-01
• Completion: 2019-04-01
• First posted: 2018-08-16
• Last updated: 2020-02-05

Locations

1 site across 1 country: Egypt