NCT03630601

Photoacoustic Imaging in Diagnosing Changes in Tumors in Participants With Breast Cancer, Sarcoma, Skin Cancer, or Soft Tissue Malignancy and Healthy Volunteers

A Pilot Study of Photoacoustic Imaging (PAI)

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Roswell Park Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This pilot trial studies how well photoacoustic imaging works in diagnosing changes in tumors in participants with breast cancer, sarcoma, skin cancer, or soft tissue malignancy and healthy volunteers. Photoacoustic imaging is a low-risk imaging method that provides information about the oxygenation of tissues using a combination of light and ultrasound techniques. Photoacoustic imaging uses a signal from hemoglobin to provide information on blood flow and oxygen levels, and it may be helpful in determining changes in tumors after chemotherapy or radiation treatment.

Detailed description

PRIMARY OBJECTIVES: I. To define the feasibility of the current photoacoustic imaging (PAI) technology in various groups of human subjects. SECONDARY OBJECTIVES: I. To define the utility of the current PAI on various groups of human subjects. II. When possible, via means of an existing data review, PAI will be correlated with standard imaging modalities performed on patients as routine part of clinical care or on protocol. III. When possible, via means of an existing data review, PAI will be compared to pathologic specimens. IV. When possible, via means of an existing data review, PAI data will be correlated with outcomes of patients to therapies they receive. OUTLINE: Participants undergo PAI on different parts of the body over 20 minutes for up to 5 imaging sessions for 6 months.

Conditions

• Breast Carcinoma
• Healthy Subject
• Malignant Soft Tissue Neoplasm
• Sarcoma
• Skin Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Photoacoustic Imaging	Undergo PAI

Timeline

• Start date: 2018-06-28
• Primary completion: 2023-03-15
• Completion: 2023-03-15
• First posted: 2018-08-15
• Last updated: 2023-03-31

Locations

1 site across 1 country: United States