NCT03629652

Head-dOwn Position for ischEmic Stroke With Middle Cerebral Artery (HOPES)

Head-dOwn Position for ischEmic Stroke With Middle Cerebral Artery (HOPES): a Prospective, Random, Multi-Center, Pilot Trial

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study is designed to explore the efficacy and safety of head-down position in patients with acute ischemic stroke。

Detailed description

Currently, the guideline recommended re-perfusion such as intravenous thrombolysis and mechanical thrombectomy as the most effective treatment for acute ischemic stroke. However, the two methods are restricted by a strict time window, which greatly limits the number of the patients receiving treatment. The abundant studies have suggested that good collateral circulation can provide compensatory blood supply to save the ischemic penumbra and reduces the infarct volume, which improves the prognosis. How to improve collateral circulation in an efficient and safe way is a clinical challenge. Our recent experiment results of the animal and clinical experiments show that head-down position can significantly increase cerebral perfusion and improve neurological function. Clinically, head-down position is simple and easy to operate, and theoretically may increases brain perfusion and improve collateral circulation. A pilot randomized clinical trial is designed to investigate the effect of head-down position combined with routine rehabilitation in patients with ischemic stroke.

Conditions

• Ischemic Stroke

Interventions

Type	Name	Description
OTHER	head-down position treatment	In the head-down position, the body is in the supine position with the head lowered to 30 degrees
OTHER	Conventional Rehabilitation	The body is in the supine position without lowered head

Timeline

• Start date: 2018-08-06
• Primary completion: 2021-06-30
• Completion: 2021-09-30
• First posted: 2018-08-14
• Last updated: 2021-11-15

Locations

1 site across 1 country: China