NCT03628625

Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage

Letrozole Pretreatment With Misoprostol for Induction of Abortion In First-Trimester Missed Miscarriage: A Randomized Controlled Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Ain Shams Maternity Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.

Detailed description

According to the American college of obstetricians and gynecologists (2005), medical abortion is an acceptable alternative for surgical procedures in pregnant women with gestational age of less than 49 days based on the last menstrual period Oral or vaginal misoprostol causes complete abortion in almost 85% of cases within seven days before the 12th week letrozole administration with misoprostol raises the rate of complete abortion Hypothesis: In women with missed miscarriage in the first trimester undergoing induction of abortion pre-treatment with letrozole before misoprostol may lead to abortion rate similar to misoprostol alone.

Conditions

• Miscarriage
• Missed Abortion

Interventions

Type	Name	Description
DRUG	Letrozole 2.5mg	total dose 7.5 mg per day for 3 days
DRUG	Placebo	Folic acid for 3 days
DRUG	Misoprostol	Misoprosrol 800mcg will be given to all patients for induction of abortion

Timeline

• Start date: 2018-09-10
• Primary completion: 2018-12-05
• Completion: 2018-12-10
• First posted: 2018-08-14
• Last updated: 2018-10-09

Locations

1 site across 1 country: Egypt