NCT03625596

Nutritional Supplements and Nitric Oxide Bioactivity

The Effects of Nutritional Supplements on Postprandial Nitric Oxide Bioactivity in Abdominally Obese Men

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Male
• Age: 40 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Obese people have a disturbed postprandial metabolism and thereby a decreased postprandial vascular function. Nitric oxide plays an important role in the postprandial vascular function. Multiple studies already focused on various nutritional compounds to improve the postprandial vascular function by increasing the nitric oxide bioactivity. However, the vast majority of the trials has been performed with relatively high doses of the individual components, which are problematic to convert into daily food measures, thereby preventing translation of these findings. Well-designed trails studying the effect of feasible amounts of nutritional supplements on the bioactivity of nitric oxide and vascular function are missing.

Conditions

• Nitric Oxide
• Vascular Function
• L-Arginine
• Nitrate / Nitrite
• Postprandial Metabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	L-Arginine	Acute intervention (3 hours)
DIETARY_SUPPLEMENT	Nitrate / Nitrite	Acute intervention (3 hours)
DIETARY_SUPPLEMENT	Placebo	Acute intervention (3 hours)

Timeline

• Start date: 2018-12-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2018-08-10
• Last updated: 2020-02-20

Locations

1 site across 1 country: Netherlands