NCT03622502

The Effect of Dexmedetomidine for Emergence Cough

The Effect of Dexmedetomidine on the Remifentanil Concentration for Preventing Cough During Emergence After Propofol Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Ajou University School of Medicine · Academic / Other
• Sex: All
• Age: 19 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

Detailed description

Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Conditions

• Cough

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine 0.5mcg/kg was infused over 10 min before end of the surgery
DRUG	Remifentanil	Remifentanil was maintained at predetermined effect-site concentration during the periextubation period (initial concentration: 2.0 ng/ml)
DRUG	Normal saline	Normal saline was infused over 10 min before end of the surgery

Timeline

• Start date: 2018-08-16
• Primary completion: 2019-03-22
• Completion: 2019-03-27
• First posted: 2018-08-09
• Last updated: 2020-01-09

Locations

1 site across 1 country: South Korea