NCT03621241

Immunophenotyping of Blood Cells in the Diagnosis Work-up of Myelodysplastic Syndromes

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by cytopenia(s), dysplasia in one or more major myeloid cell lines and progression to acute leukemia. Morphological analysis of peripheral blood (PB) and bone marrow (BM) remains the cornerstone of the diagnosis. Preliminary studies identified Flow Cytometry (FC) markers on red cells, platelets and circulating leukocytes that are expressed differently in MDS and in controls. However, these markers have been evaluated separately. The investigators propose to test in a large cohort of patients these markers, and to combine the most relevant ones in order to define a PB FC-based diagnosis score that would discriminate between MDS and non-clonal hematopoiesis and would avoid useless bone marrow samples in elderly

Conditions

• Myelodysplastic Syndromes

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Flow cytometry	Flow cytometry

Timeline

• Start date: 2018-06-15
• Primary completion: 2024-08-01
• Completion: 2024-12-01
• First posted: 2018-08-08
• Last updated: 2024-07-10

Locations

3 sites across 1 country: France