NCT03619512

Genomic and Proteomic Study of Richter Syndrome (CGPSR)

Genomic and Proteomic Study of Richter Syndrome

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 170 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Biological study on Richter Syndrome (RS), an agressive lymphoma that arises from Chronic Lymphocytice Leukemia (CLL). RS presents with the same histological aspect as primitive Diffuse Large B-Cell Lymphoma (DLBCL), but is associated with a poor prognosis, due to chemorefractoriness. This study aims at understanding the biological determinants of chemotherapy resistance in Richter Syndrome.

Detailed description

With the help of the French National Research Group on CLL (FILO / French Innovative Leukemia Organization), the investigators are currently gathering fresh frozen cell pellets at CLL stage, and lymph node biopsies at Richter stage. The investigators also gathered lymph node biopsies from DLBCL, as a reference group. The investigators will perform genomic and proteomic comparative studies between CLL and Richter, as well as between Richter and primitive DLBCL, to understand the biological determinants of clonal evolution and chemorefractoriness of Richter Syndrom.

Conditions

• Richter Syndrome

Interventions

Type	Name	Description
GENETIC	Whole exome sequencing.	Retrospective biological exploration of the samples, including tumoral DNA exploration.
GENETIC	RNA sequencing	Characterization of tumor transcriptomic profile.
OTHER	Mass spectrometry	Characterization of tumor proteomic profiles.

Timeline

• Start date: 2017-09-06
• Primary completion: 2023-12-31
• Completion: 2024-09-05
• First posted: 2018-08-08
• Last updated: 2023-03-24

Locations

1 site across 1 country: France