NCT03616535

Interventions Made to Preserve Cognitive Function

Hemodialysis-based Interventions to Preserve Cognitive Function

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 130 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators will test three interventions cognitive training (CT), exercise training (ET), and combined cognitive and exercise training (CT+ET) relative to standard of care (SC).

Detailed description

This will be a two by two factorial, randomized, controlled trial to slow cognitive decline in adults undergoing hemodialysis (HD). The investigators primary objective is to determine if receiving cognitive training (tablet-based brain games), exercise training (stationary foot pedal), or combined cognitive and exercise training preserves executive function relative to those with standard of care . The secondary objectives are to compare the rates of end stage renal disease (ESRD)-specific clinical outcomes and patient centered outcomes among those receiving CT, or ET, or CT+ET relative to those in SC. The investigators will formally test whether receiving CT or ET will preserve executive function and receiving combined CT+ET will preserve executive function better than CT or ET alone.

Conditions

• ESRD

Interventions

Type	Name	Description
OTHER	Cognitive training	The investigators will provide participants with tablets to play brain games.
OTHER	Exercise training	The investigators will provide participants with foot peddlers.
OTHER	Combined cognitive and exercise training	The investigators will provide participants with tablets to play brain games for cognitive training and stationary foot peddlers for exercise training.

Timeline

• Start date: 2018-08-30
• Primary completion: 2023-06-23
• Completion: 2023-09-20
• First posted: 2018-08-06
• Last updated: 2025-07-16
• Results posted: 2025-04-11

Locations

2 sites across 1 country: United States