NCT03616002

Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

Effects of Hookah Smoking on Vascular Regulation: Novel Insight Into Endothelial Function

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (estimated)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 29 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Detailed description

The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.

Conditions

• Hookah Smoking

Interventions

Type	Name	Description
OTHER	Hookah smoking	ad lib hookah smoking for 30 minutes in a controlled laboratory environment.

Timeline

• Start date: 2015-01-01
• Primary completion: 2020-03-01
• Completion: 2020-03-01
• First posted: 2018-08-06
• Last updated: 2021-02-04

Locations

1 site across 1 country: United States