NCT03615989

The Combined Effect of Dairy and Exercise on Bone and Inflammation

Does Milk Augment the Acute Effect of Exercise on Bone Turnover and Inflammation

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: York University · Academic / Other
• Sex: Female
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study analyzes whether dairy supplementation positively impacts loading exercise-induced bone cell activity and inflammation in healthy young females.

Detailed description

Introduction: Two million individuals at a cost of around 2.3 billion dollars a year in Canada suffer from osteoporosis. Research that emphasizes the treatment of this disease is important, but so is research that focuses on prevention; reducing bone loss and/or increasing bone mass when young. In addition, inflammation is an issue as it strongly relates to chronic disease. Countermeasures to improve bone health and inflammation, such as nutrition and exercise, should be explored and implemented. The proposed research combines both nutrition and exercise along with the assessment of bone turnover markers and inflammation in healthy young females, and aims to determine whether dairy versus a carbohydrate-based beverage positively impacts acute bone turnover and the inflammatory response following a bout of resistance and plyometric exercise. Design: Randomized controlled crossover trial. Participants: 13 healthy university aged females. Methods: Participants were asked to complete 2 different acute exercise and nutritional supplement trials. Each trial will be assigned in random order. The two trials were: 1) exercise+carbohydrate (CHO), and 2) exercise+milk (Milk). The whole study, per participant, took a maximum of 8-12 weeks to complete as each supplement trial was separated by \~4 weeks. Each treatment is outlined below. \*\*\*\*\*\*DUE TO COVID-19, we removed the treatment trial which involved milk+creatine supplementation. Despite randomization, and before the trial was closed, only 11 participants completed this trial\*\*\*\*\*\*\*\* Anticipated Results: The investigators anticipate that dairy and exercise will have a greater positive impact on acute bone cell activity and inflammation in healthy young females compared to exercise and CHO.

Conditions

• Healthy
• Females
• Bone
• Inflammation

Interventions

Type	Name	Description
BEHAVIORAL	Resistance and Plyometric Exercise	A single resistance and plyometric exercise bout per trial.
DIETARY_SUPPLEMENT	Carbohydrate (Maltodextrin powder mixed with water)	50 grams immediately after exercise bout. 50 grams 1 hour after exercise bout.
DIETARY_SUPPLEMENT	Skim Milk	500 ml immediately after exercise bout. 500 ml 1 hour after exercise bout.

Timeline

• Start date: 2018-10-01
• Primary completion: 2020-03-14
• Completion: 2020-03-14
• First posted: 2018-08-06
• Last updated: 2021-05-18

Locations

1 site across 1 country: Canada