NCT03615781

Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 85 (actual)
• Sponsor: University Hospital, Geneva · Academic / Other
• Sex: All
• Age: 18 Years – 120 Years
• Healthy volunteers: Not accepted

Summary

The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and a four week's randomization arm

Detailed description

The optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allocating patients into a two-week's and a four week's randomization arm. The adult patients are hospitalized for septic arthritis. A computer program randomizes 1:1 between a two week's and a four week's arm of targeted antibiotic treatment of which at least the first week is intravenously. The randomization may occur until Day 5 of admission. Up to three surgical interventions are allowed. The investigators allow the inclusion of all bacterial arthritis and all joints.

Conditions

• Arthritis, Septic

Interventions

Type	Name	Description
PROCEDURE	Two week's arm - surgery	The investigators perform a surgical drainage of the infection along with the complete removal of the infected orthopedic implant.
PROCEDURE	Four week's arm - surgery	The investigators perform a surgical drainage of the infection along with the complete removal of the infected orthopedic implant.
DRUG	Two week's arm - drugs	After the surgical implant removal, the investigators prescribe a total of 2 weeks of systemic targeted antibiotic therapy against the causative pathogen(s), of which one week is recommended to be intravenously.
DRUG	Four week's arm - drugs	After the surgical implant removal, the investigators prescribe a total of 4 weeks of systemic targeted antibiotic therapy against the causative pathogen(s), of which one week is recommended to be intravenously.

Timeline

• Start date: 2015-06-01
• Primary completion: 2018-04-01
• Completion: 2018-05-18
• First posted: 2018-08-06
• Last updated: 2018-08-06

Locations

1 site across 1 country: Switzerland