NCT03614520

Evaluation of Bioavailability and Metabolism of Diet Phenolic Compounds

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Parc de Salut Mar · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study aims at studying in depth the absorption and metabolism of phenolic compounds of olive oil, wine and beer. This study is divided into 2 sub-studies in order to evaluate each one of the objectives.

Detailed description

The study is divided in two sub-studies to explore each objective. One the one hand, a group of people will drink olive oil, or wine, or both. This is done to see if combining these two drinks will improve the absorption and bioavailibility of phenolic compounds that they contain, promoting by synergy their antioxidant activity at a postprandial level. The main compounds studied are the Resveratrol (RSVT), the Hydroxytyrosol (HT), tyrosol (TIR) and their metabolits. One the other hand, an group of people will drink 3 different beers ( with 3 different degrees of alcohol), or wine, in order to study the absorption of TIR in relation to the alcohol degree. It also aims at assessing if the gas contained in beer contributes to TIR absorption. At different times after the administration of drinks, urine and blood samples will be collected.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Administration of olive oil	25 mL of extra virgin olive oil
OTHER	Administration of red wine	150 mL or Red Wine
OTHER	Combination of red wine and olive oil	150 mL of Red wine + 25 mL of Extra Virgin Olive oil will be administred at the same time
OTHER	Water	Mineral water will be given as placebo
OTHER	Dark beer	250 mL of IPA beer (alcohol 8.5% vol)
OTHER	Light Beer	250 mL of blonde ale beer (alcohol 4,5% vol)
OTHER	Alcohol free Beer	250 mL of alcohol free beer (alcohol 0.0% vol)

Timeline

• Start date: 2018-07-09
• Primary completion: 2019-02-27
• Completion: 2019-02-27
• First posted: 2018-08-03
• Last updated: 2020-03-05

Locations

1 site across 1 country: Spain