NCT03613974

Minimum Anaesthesia Concentration of Lidocaine Required for Sciatic Popliteal Block

Successful Popliteal Block Using Lidocaine; What is the Minimum Effective Anesthesia Concentration (MEAC90)

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Healthpoint Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

using a biased-coin design up-down sequential method, different concentration of lidocaine will be used for popliteal block After 45 successful block (positive response), the data will be used to calculate the minimum lidocaine concentration that can result in successful popliteal block in 90% of patients

Detailed description

The response of a patient determined the lidocaine concentration given to the next patient (a biased-coin design up-down sequential method). If a patient had a negative response, the lidocaine concentration was increased by 0.1% w/v in the next patient. If a patient had a positive response, the next patient was randomized to receive the same lidocaine concentration (with probability of 0.89), or to receive a concentration 0.1% w/v less (with probability of 0.11).

Conditions

• Orthopedic Procedures

Interventions

Type	Name	Description
DRUG	Lidocaine	patients will receive different lidocaine concentrations

Timeline

• Start date: 2018-12-15
• Primary completion: 2019-03-15
• Completion: 2019-03-31
• First posted: 2018-08-03
• Last updated: 2018-11-14