NCT03613506

The Role and Intervention of TGF-β in Abdominal Radiation Injury

The Role of TGF-β in Abdominal Radiation Injury and Taking Medicine to Block TGF-β for Protecting Normal Organization

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 226 (estimated)
• Sponsor: Wuhan University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This project aims to investigate the relationship between radiation-induced the relationship between elevated peripheral blood TGFβ and complications of radiotherapy,and to analysis of changes in peripheral blood TGFβ levels after abdominal radiotherapy and its relationship with radiotherapy complications.Simultaneously,Patients who underwent abdominal radiotherapy were given captopril (sustained release) to block TGFβ,Whether it can reduce peripheral blood TGFβ levels and reduce radiotherapy complications,to explore the protective effect of blocking TGFβ secretion on normal tissues after radiotherapy.

Conditions

• Radiotherapy Side Effect
• Taking Captopril

Interventions

Type	Name	Description
DRUG	Captopril 12.5 Mg	Taking captopril 12.5mg b.i.d for two months before radiotherapy.

Timeline

• Start date: 2019-10-25
• Primary completion: 2022-06-25
• Completion: 2022-12-25
• First posted: 2018-08-03
• Last updated: 2022-02-14

Locations

1 site across 1 country: China