NCT03612713

Influence of Medication on Functional Connectivity

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals

Detailed description

This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals (N=40, 20 male, 20 female). The objective of this research is to develop an understanding of factors that may influence individual variability on resting state functional connectivity in response to low-dose opioid administration with the longer term aim of understanding addictions vulnerability. Specifically, the proposed pilot research will explore the effects of single dose of oxycodone (15mg) on resting state functional connectivity and other common neuroimaging measures (e.g., diffusion MRI, structural MRI).

Conditions

• Prescription Drug Abuse (Not Dependent)

Interventions

Type	Name	Description
DRUG	Oxycodone Medication First	Participants will be given 15mg oxycodone one hour before fMRI scan. After at least 1 week wash out participants will be given placebo one hour before fMRI scan.
DRUG	Placebo First	Participants will be given placebo one hour before fMRI scan. After at least 1 week wash out participants will be given 15mg oxycodone one hour before fMRI scan.

Timeline

• Start date: 2018-10-30
• Primary completion: 2022-06-02
• Completion: 2022-06-02
• First posted: 2018-08-02
• Last updated: 2024-03-08
• Results posted: 2024-03-08

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study