NCT03611920

Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Teeth

Effect of Topical Tetracycline and Dexamethasone on Periodontal and Pulpal Regeneration of Replanted Avulsed Permanent Teeth: A Long-term Follow-up After 9-16 Years

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 33 (actual)
• Sponsor: University of Bern · Academic / Other
• Sex: All
• Age: 6 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.

Detailed description

Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined. Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.

Conditions

• Dental Trauma
• Avulsion
• Periodontal Regeneration
• Pulpal Regeneration
• Topical Dexamethasone
• Topical Tetracycline

Interventions

Type	Name	Description
PROCEDURE	Tetracycline	Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation
PROCEDURE	Dexamethasone	Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation

Timeline

• Start date: 2000-08-14
• Primary completion: 2017-10-05
• Completion: 2017-10-05
• First posted: 2018-08-02
• Last updated: 2018-08-21

Locations

1 site across 1 country: Switzerland