NCT03611465

Creation of a Pace-mapping Atlas on Healthy and Pathological Hearts

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 117 (estimated)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Aim of this study is to collect data from pace mapping performed in three groups of patients : patients presenting ventricular tachycardia and infarction history, patients presenting infarction history without presenting ventricular tachycardia, and in patients without structural heart disease.

Detailed description

Ventricular tachycardia (VT) represent an important problem in western countries. 350 000 deaths are attributable to ventricular arrhythmias in Europe every year. The gold standard treatment is to implant a cardiac defibrillator that will be able to stop arrhythmia by delivering pacing or internal shocks. In order to avoid internal shocks, ablation techniques have been developed, consisting in placing catheters in the left ventricle, to induce the VT, and then to perform a mapping of its circuit. Once this circuit is clearly defined, ablation of the critical part of the circuit, so called VT isthmus can be performed, using a radiofrequency power. One of the limitations of this technique is that it requires VT induction during the procedure, and that the VT lasts long enough to enable its mapping. Nancy University Hospital developed a technique using pace mapping to define the VT isthmus even when the VT is not sustained. The pace mapping technique enables to reveal conduction troubles in the studied ventricles, that correspond with the VT isthmus. During this study, the investigators will collect pace-mapping data from ventricles of patient presenting infarction history and VT, from patients with infarction history without VT, and from patients without ventricular pathology.

Conditions

• Ventricular Tachycardia

Interventions

Type	Name	Description
OTHER	Pace-mapping	Acquire pace-mapping on three distinct populations to better understand the influence of heart disease on electrical conduction.
OTHER	Standard pace-mapping examination	Acquire pace-mapping on three distinct populations to better understand the influence of heart disease on electrical conduction.

Timeline

• Start date: 2018-10-26
• Primary completion: 2023-10-26
• Completion: 2024-04-26
• First posted: 2018-08-02
• Last updated: 2022-08-09

Locations

1 site across 1 country: France