NCT03611400

The Effect of Probiotic Intake on Intestinal Permeability in Healthy Adults

The Effect of Probiotic Intake on Intestinal Permeability of Healthy Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Accepted

Summary

In this double blind, crossover study participants will take a placebo for 3 weeks each. Gut permeability will be assessed weekly using food-grade sugar molecules. On the second week, participants will take aspirin, which will make their intestine permeable to the sugars. Participants will be asked to provide urine and stool samples to assess gut permeability and microbial communities. No change in permeability to the small sugar probes is anticipated with the probiotic.

Conditions

• Intestinal Barrier Function

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic	This probiotic is commercially available and contains L. helveticus R0052 (0.2 x 10\^9 CFU/capsule) and L. rhamnosus R0011 (3.8 x 10\^9 CFU/capsule) as active ingredients and ascorbic acid, hypromellose, magnesium stearate, saccharose, potato starch, titanium dioxide, and maltodextrin as excipients.
DIETARY_SUPPLEMENT	Placebo	The placebo contains ascorbic acid, hypromellose, magnesium stearate, saccharose, potato starch, titanium dioxide and maltodextrin.

Timeline

• Start date: 2018-08-22
• Primary completion: 2019-04-15
• Completion: 2019-04-15
• First posted: 2018-08-02
• Last updated: 2019-06-21

Locations

1 site across 1 country: United States