NCT03611257

Effect of dRAST on Treatment for Bacteremia in Patients With Hematologic Diseases

Effect of Direct Rapid Antibiotic Susceptibility Testing (dRAST) on Treatment for Bacteremia in Patients With Hematologic Diseases: Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate whether the use of direct rapid antibiotic susceptibility test (dRAST), in addition to the current standard antibiotic susceptibility test, can increase the proportion of patients with hematologic disease who received appropriate antibiotics in early period of bacteremia.

Detailed description

* patients with hematologic diseases who have high risk of bacteremia, because of immune suppression treatment or intensive chemotherapy or bone marrow transplantation which these patients had received, will be recruited in tertiary referral medical centers. * All the participants will be randomly assigned into either dRAST group or current standard antibiotic susceptibility test group. * All the participants in the both arms will receive antimicrobial stewardship by infectious disease specialists. Antimicrobial stewardship will be performed at each timepoint of Gram stain results reporting, dRAST results reporting, and current method reporting. * Target numbers are 58 and 58, respectively. * All the participants will be monitored for general medical conditions such as vital sign and response to antibiotic treatment by infectious disease specialists for 1 week. * The percentage of patients who received optimal targeted antibiotics 72 hours after blood collection for blood culture will be evaluated.

Conditions

• Hematologic Diseases
• Bacteremia Sepsis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	dRAST	Infectious diseases specialists will do active antimicrobial stewardship according to dRAST results in addition to Gram staining results and current standard method.
DIAGNOSTIC_TEST	Current standard method	Infectious diseases specialists will do active antimicrobial stewardship according to Gram staining results, and current standard method without dRAST results.

Timeline

• Start date: 2018-09-01
• Primary completion: 2019-09-15
• Completion: 2019-10-10
• First posted: 2018-08-02
• Last updated: 2019-10-14

Locations

1 site across 1 country: South Korea