NCT03607071

Outcome of Steroid Therapy for Myocardial Inflammation in Scleroderma

Outcome of Myocardial Inflammation After Steroid Therapy in Thai Systemic Sclerosis Patients: an Open Label Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Khon Kaen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Primary myocardial involvement is common in scleroderma, effected to pericardium, vascular, conducting defect and especially myocardium. Cardiac MRI is widely used for assessment of cardiac involvement in scleroderma, both structural and functional pathology. Cardiac MRI has a diagnostic accuracy of 85% for the detection of myocardial inflammation. Nowadays, the treatment of myocardial inflammation in scleroderma is uncertain. The investigator's study aims to define the cardiac outcome after moderate dose steroid therapy in the patients who have myocardial inflammation detection by cardiac MRI.

Conditions

• Myocardial Inflammation

Interventions

Type	Name	Description
DRUG	Prednisolone and taper	Prednisolone 30 mg/d and taper 5-10 mg per 2 weeks until off at week 24.

Timeline

• Start date: 2018-05-15
• Primary completion: 2019-06-30
• Completion: 2019-06-30
• First posted: 2018-07-31
• Last updated: 2020-09-09

Locations

1 site across 1 country: Thailand