Trials / Unknown
UnknownNCT03606954
Potency of Topical Corticosteroids in Combination Preparations
Evaluation of Topical Corticosteroids Potency in Combination Preparations in Healthy Volunteers
- Status
- Unknown
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- Sponsor
- Ben-Gurion University of the Negev · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Several combination topical drugs are available on the market. The potency of corticosteroids depends on a particular molecular structure and the skin penetration properties. Besides molecular structure, a penetration of a corticosteroid molecule correlates with physical properties of the vehicle which depend on physical properties of the vehicle constituents. Vasoconstriction assay is considered as the gold standard for testing potency of topical corticosteroids.
Detailed description
Primary outcome: Change in Vasoconstriction index following application of topical corticosteroids that are incorporated with or without an antibiotic and/or antifungal drugs in healthy volunteers.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| COMBINATION_PRODUCT | Combination topical corticosteroid | Comparison of a vasoconstriction index between the 2 study arms |
Timeline
- Start date
- 2018-11-01
- Primary completion
- 2019-03-01
- Completion
- 2019-04-01
- First posted
- 2018-07-31
- Last updated
- 2018-07-31
Source: ClinicalTrials.gov record NCT03606954. Inclusion in this directory is not an endorsement.