NCT03606434

Sex Differences in Reflex Responses to Intermittent Hypoxia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of the present study is to determine whether there are sex differences in the reflex responses to hypoxia in humans.

Detailed description

Over 35% of the US population will develop sleep apnea at some point in their life. Sleep apnea is the most common form of sleep disordered breathing and patients with sleep apnea are at increased risk of developing high blood pressure. Intermittent, repeated exposures to low oxygen during sleep (intermittent hypoxia, IH) has been implicated as the primary stimulus for increases in sympathetic nervous system activity and blood pressure with sleep apnea. Interestingly there are some reports of a lower incidence of hypertension in women with sleep apnea when compared to men. Results from the present study will provide information important to the investigator's understanding of potential sex-differences in clinical outcomes for conditions related to acute/chronic hypoxia and may have important implications for treatments which may improve blood pressure control in patients with sleep apnea.

Conditions

• Healthy Participants

Interventions

Type	Name	Description
OTHER	Hypoxic exposure	30 minutes of intermittent hypoxia

Timeline

• Start date: 2018-09-13
• Primary completion: 2021-07-15
• Completion: 2021-07-15
• First posted: 2018-07-30
• Last updated: 2021-07-21

Locations

1 site across 1 country: United States