NCT03604107

Predictive Value of Embryonic Testing

Evaluation of the Efficacy of Preimplantation Genetic Screening (PGS) in Predicting Embryonic Ploidy and Subsequent Pregnancy Outcomes in in Vitro Fertilization (IVF) Cycles

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 237 (actual)
• Sponsor: Reproductive Medicine Associates of New Jersey · Academic / Other
• Sex: Female
• Age: 18 Years – 42 Years
• Healthy volunteers: —

Summary

The primary objective of this study is to determine the predictive value of preimplantation genetic screening (PGS) as a marker of embryonic competence. Secondary objectives are to define the related or independent predictive values of other proposed markers of embryonic and maternal reproductive competence in assisted reproductive technology (ART) cycles.

Detailed description

Patients participating in the study will undergo a routine in vitro fertilization cycle. Trophectoderm biopsy will be performed on all blastocysts however biopsy samples will not be analyzed till the clinical outcome has been determined. The single, morphologically best embryo available will be selected for transfer. All clinical and laboratory care is identical to that of which subjects would receive if they were not participating in the study. This includes all pretreatment screening, in-cycle treatment, embryology procedures, single embryo transfer, pregnancy testing, and pregnancy follow-up (if pregnancy occurs).

Conditions

• Infertility

Interventions

Type	Name	Description
GENETIC	Preimplantation Genetic Testing-Aneuploidy	trophectoderm biopsy samples will be analyzed for karyotype after clinical outcome is determined

Timeline

• Start date: 2018-07-30
• Primary completion: 2020-09-30
• Completion: 2020-12-01
• First posted: 2018-07-27
• Last updated: 2022-01-14

Locations

4 sites across 1 country: United States