NCT03604003

The Role of Isolated Nocturnal Hypertension Pattern in Nondialysis CKD

Prognostic Effect of Isolated Nocturnal Hypertension Pattern With Nondialysis CKD

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 252 (estimated)
• Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University · Academic / Other
• Sex: All
• Age: 14 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Isolated nocturnal hypertension (INH) has been studied among the general population and hypertensive patients. However, little insight is available on the prognostic effect of INH in patients with chronic kidney disease (CKD). This study investigated the prognostic effect of INH in a cohort of Chinese patients with nondialysis CKD.

Detailed description

Patients with or without isolated nocturnal hypertension will be enrolled in this study, and the patients with isolated nocturnal hypertension will be randomly divided into two groups and treated with bedtime or awakening doses of potassium losartan. Any patients who had any antihypertension medication at bedtime would withdrawal the drugs for 2 weeks before ABPM. Patients with isolated nocturnal hypertension will be randomly divided into two groups and received a bedtime or awakening dose of potassium losartan.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	potassium losartan	treated with bedtime or awakening doses of potassium losartan

Timeline

• Start date: 2018-11-30
• Primary completion: 2021-06-30
• Completion: 2023-12-30
• First posted: 2018-07-27
• Last updated: 2018-07-27